Eletriptan Uses Eletriptan is used in Acute migraine headache. It relieves the symptoms of migraine and prevents the attack from becoming worse. How Eletriptan works Migraine headaches are thought to result from the dilatation of blood vessels in the brain and release of vasoactive and pro-inflammatory peptides (chemical messenger) from sensory nerve endings. Eletriptan is a selective 5-hydroxytryptamine 1B/1D receptor agonist. It works by constricting (narrowing) these blood vessels and prevents the release of the chemical messenger in the nerve endings, thereby relieving the migraine headaches. Common side effects of Eletriptan Chest pain, Dizziness, Flushing (sense of warmth in the face, ears, neck and trunk), Nausea, Weakness, Headache, Paresthesia (tingling or pricking sensation), Abdominal discomfort.